Metastatic Melanoma News

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Obesity Associated With Improved Outcomes in Some Metastatic Melanomas - Cancer Network



Obesity Associated With Improved Outcomes in Some Metastatic Melanomas 
Cancer Network
A retrospective review found that obesity is associated with improved progression-free and overall survival in patients with metastatic melanoma. The benefit was largely restricted to male patients, and to those who received targeted therapy or ...

 


Obesity Individuals May Have Greater Metastatic Melanoma Survival Odds - Monthly Prescribing Reference



Obesity Individuals May Have Greater Metastatic Melanoma Survival Odds 
Monthly Prescribing Reference
The researchers found that, compared with normal BMI, obesity was correlated with improved survival for patients with metastatic melanoma in the pooled analysis (average adjusted hazard ratio, 0.77 for progression-free survival and 0.74 for overall ...

 


Abl and Arg mediate cysteine cathepsin secretion to facilitate melanoma invasion and metastasis - Science



Abl and Arg mediate cysteine cathepsin secretion to facilitate melanoma invasion and metastasis 
Science
Melanoma cells secrete proteases called cathepsins, which degrade the extracellular matrix and facilitate cell migration and invasion. Tripathi et al. found that cathepsin secretion was promoted by the nonreceptor tyrosine kinase Abl. Activation of Abl ...

 


Current Landscape of Immuno-Oncology in Advanced Melanoma - AJMC.com Managed Markets Network



Current Landscape of Immuno-Oncology in Advanced Melanoma 
AJMC.com Managed Markets Network
Melanoma is the most lethal type of skin cancer.1 In 2017, approximately 87,110 new cases of melanoma will be diagnosed and approximately 9730 deaths will occur due to the disease.2 Compared with individuals younger than 50 years, individuals 50 years ...

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Obesity associated with longer survival for men with metastatic melanoma - Science Daily



Obesity associated with longer survival for men with metastatic melanoma 
Science Daily
"The question is what underlying mechanism causes this advantage in obese men, and can we take advantage of it to improve outcomes in patients with melanoma?" McQuade said. "One hint may be the interaction between obesity, sex, and outcomes, which has ...

 


'Obesity Paradox' Offers Puzzling Survival Advantage in Men with Metastatic Melanoma - Curetoday.com



MedicalResearch.com (blog)
 
'Obesity Paradox' Offers Puzzling Survival Advantage in Men with Metastatic Melanoma 
Curetoday.com
While obesity is a known risk factor for more than a dozen types of cancer ? and poised to take over smoking as the leading preventable cause for the disease ? it may actually play a beneficial role in men with metastatic melanoma, according to a ...
Another Obesity Paradox: Obese Males Have Survival Advantage in Melanoma MedicalResearch.com (blog)

all 2 news articles » 


Obesity Tied to Survival in Men With Melanoma - New York Times



New York Times
 
Obesity Tied to Survival in Men With Melanoma 
New York Times
Obese men treated for metastatic melanoma may survive longer than their normal-weight peers. Researchers did a retrospective analysis of 1,918 people, 1,155 of them men, under treatment for metastatic melanoma. The study is in Lancet Oncology. Compared ...
Obese Males May Have Melanoma Survival Advantage Genetic Engineering & Biotechnology News
Study reports longer survival for obese men with metastatic melanoma News-Medical.net

all 4 news articles » 


Intriguing: Better Survival in Melanoma in Obese Men - Medscape



Medscape
 
Intriguing: Better Survival in Melanoma in Obese Men 
Medscape
An analysis of nearly 2000 patients with metastatic melanoma who were treated with targeted therapies or immunotherapies has found that for patients who were classified as obese (ie, who had a body mass index [BMI] ?30), survival was significantly ...

 


Metastatic Melanoma Patients May Benefit From Beta Blockers - Cancer Network



Metastatic Melanoma Patients May Benefit From Beta Blockers 
Cancer Network
In studies developed by Kathleen Kokolus, MD, a postdoctoral fellow at Penn State, the researchers analyzed data from 195 metastatic melanoma patients who were treated with immunotherapy between 2000 and 2015. Among the 195 patients, 62 were also ...

 


Trending News Today: Obesity Linked to Higher Metastatic Melanoma Survival in Men - Specialty Pharmacy Times



Trending News Today: Obesity Linked to Higher Metastatic Melanoma Survival in Men 
Specialty Pharmacy Times
House GOP leaders are discussing repealing or delaying the Affordable Care Act employer mandate, according to The Hill. House Ways and Means Committee Chairman Kevin Brady (R-TX) said that he has discussed the topic with members of the committee and ...